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small-molecule inhibitors of alk  (Cephalon Inc)

 
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    Cephalon Inc small-molecule inhibitors of alk
    Small Molecule Inhibitors Of Alk, supplied by Cephalon Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/small-molecule inhibitors of alk/product/Cephalon Inc
    Average 90 stars, based on 1 article reviews
    small-molecule inhibitors of alk - by Bioz Stars, 2026-02
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    A: Sub-confluent HUAECs were transfected with specified siRNAs , protein lysates were harvested 48 hours later, following the indicated treatments for 0, 1 or 24 hours with BMP9 (2ng/ml), and assayed by Western blot (left) with B: Histograms (right) showing quantification of proteins relative to siNT -transfected HUAECs. C: Schematic of BMP9-ALK-1-SMAD4 signaling. D&E : Western blot from HUAEC treated with 2ng/ml of BMP9 for 24h using siNT compared to siPTPN14 showing the effect of PTPN14 on Endoglin and SMAD4 level with the quantification graph ( E ). F : siRNA-treated cells Western blot of HUAECs cell lysates after 1h treatment with TGFβ (2ng/ml) or BMP9 (2ng/ml), with or without 5uM <t>K02288</t> (an ALK-1 inhibitor) or 5uM SB431542 (a TGFβR1 inhibitor) with the observation of SMAD4, pSMAD1 and total Smad1 level trough the different conditions. G: Co-immunoprecipitation of endogenous PTPN14, SMAD4, Endoglin, ALK-1 SMAD7, or IgG control, shows interaction between endogenous PTPN14 and SMAD4,but not with Endoglin, ALK-1 and, SMAD7. H: SMAD4 pulldown with SMAD4, TAZ, pTAZ, pSAMD1/5, and SMAD7 is showing the interaction of SMAD4 with the different proteins.
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    A: Sub-confluent HUAECs were transfected with specified siRNAs , protein lysates were harvested 48 hours later, following the indicated treatments for 0, 1 or 24 hours with BMP9 (2ng/ml), and assayed by Western blot (left) with B: Histograms (right) showing quantification of proteins relative to siNT -transfected HUAECs. C: Schematic of BMP9-ALK-1-SMAD4 signaling. D&E : Western blot from HUAEC treated with 2ng/ml of BMP9 for 24h using siNT compared to siPTPN14 showing the effect of PTPN14 on Endoglin and SMAD4 level with the quantification graph ( E ). F : siRNA-treated cells Western blot of HUAECs cell lysates after 1h treatment with TGFβ (2ng/ml) or BMP9 (2ng/ml), with or without 5uM <t>K02288</t> (an ALK-1 inhibitor) or 5uM SB431542 (a TGFβR1 inhibitor) with the observation of SMAD4, pSMAD1 and total Smad1 level trough the different conditions. G: Co-immunoprecipitation of endogenous PTPN14, SMAD4, Endoglin, ALK-1 SMAD7, or IgG control, shows interaction between endogenous PTPN14 and SMAD4,but not with Endoglin, ALK-1 and, SMAD7. H: SMAD4 pulldown with SMAD4, TAZ, pTAZ, pSAMD1/5, and SMAD7 is showing the interaction of SMAD4 with the different proteins.
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    A: Sub-confluent HUAECs were transfected with specified siRNAs , protein lysates were harvested 48 hours later, following the indicated treatments for 0, 1 or 24 hours with BMP9 (2ng/ml), and assayed by Western blot (left) with B: Histograms (right) showing quantification of proteins relative to siNT -transfected HUAECs. C: Schematic of BMP9-ALK-1-SMAD4 signaling. D&E : Western blot from HUAEC treated with 2ng/ml of BMP9 for 24h using siNT compared to siPTPN14 showing the effect of PTPN14 on Endoglin and SMAD4 level with the quantification graph ( E ). F : siRNA-treated cells Western blot of HUAECs cell lysates after 1h treatment with TGFβ (2ng/ml) or BMP9 (2ng/ml), with or without 5uM <t>K02288</t> (an ALK-1 inhibitor) or 5uM SB431542 (a TGFβR1 inhibitor) with the observation of SMAD4, pSMAD1 and total Smad1 level trough the different conditions. G: Co-immunoprecipitation of endogenous PTPN14, SMAD4, Endoglin, ALK-1 SMAD7, or IgG control, shows interaction between endogenous PTPN14 and SMAD4,but not with Endoglin, ALK-1 and, SMAD7. H: SMAD4 pulldown with SMAD4, TAZ, pTAZ, pSAMD1/5, and SMAD7 is showing the interaction of SMAD4 with the different proteins.
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    A: Sub-confluent HUAECs were transfected with specified siRNAs , protein lysates were harvested 48 hours later, following the indicated treatments for 0, 1 or 24 hours with BMP9 (2ng/ml), and assayed by Western blot (left) with B: Histograms (right) showing quantification of proteins relative to siNT -transfected HUAECs. C: Schematic of BMP9-ALK-1-SMAD4 signaling. D&E : Western blot from HUAEC treated with 2ng/ml of BMP9 for 24h using siNT compared to siPTPN14 showing the effect of PTPN14 on Endoglin and SMAD4 level with the quantification graph ( E ). F : siRNA-treated cells Western blot of HUAECs cell lysates after 1h treatment with TGFβ (2ng/ml) or BMP9 (2ng/ml), with or without 5uM <t>K02288</t> (an ALK-1 inhibitor) or 5uM SB431542 (a TGFβR1 inhibitor) with the observation of SMAD4, pSMAD1 and total Smad1 level trough the different conditions. G: Co-immunoprecipitation of endogenous PTPN14, SMAD4, Endoglin, ALK-1 SMAD7, or IgG control, shows interaction between endogenous PTPN14 and SMAD4,but not with Endoglin, ALK-1 and, SMAD7. H: SMAD4 pulldown with SMAD4, TAZ, pTAZ, pSAMD1/5, and SMAD7 is showing the interaction of SMAD4 with the different proteins.
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    A: Sub-confluent HUAECs were transfected with specified siRNAs , protein lysates were harvested 48 hours later, following the indicated treatments for 0, 1 or 24 hours with BMP9 (2ng/ml), and assayed by Western blot (left) with B: Histograms (right) showing quantification of proteins relative to siNT -transfected HUAECs. C: Schematic of BMP9-ALK-1-SMAD4 signaling. D&E : Western blot from HUAEC treated with 2ng/ml of BMP9 for 24h using siNT compared to siPTPN14 showing the effect of PTPN14 on Endoglin and SMAD4 level with the quantification graph ( E ). F : siRNA-treated cells Western blot of HUAECs cell lysates after 1h treatment with TGFβ (2ng/ml) or BMP9 (2ng/ml), with or without 5uM <t>K02288</t> (an ALK-1 inhibitor) or 5uM SB431542 (a TGFβR1 inhibitor) with the observation of SMAD4, pSMAD1 and total Smad1 level trough the different conditions. G: Co-immunoprecipitation of endogenous PTPN14, SMAD4, Endoglin, ALK-1 SMAD7, or IgG control, shows interaction between endogenous PTPN14 and SMAD4,but not with Endoglin, ALK-1 and, SMAD7. H: SMAD4 pulldown with SMAD4, TAZ, pTAZ, pSAMD1/5, and SMAD7 is showing the interaction of SMAD4 with the different proteins.
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    A: Sub-confluent HUAECs were transfected with specified siRNAs , protein lysates were harvested 48 hours later, following the indicated treatments for 0, 1 or 24 hours with BMP9 (2ng/ml), and assayed by Western blot (left) with B: Histograms (right) showing quantification of proteins relative to siNT -transfected HUAECs. C: Schematic of BMP9-ALK-1-SMAD4 signaling. D&E : Western blot from HUAEC treated with 2ng/ml of BMP9 for 24h using siNT compared to siPTPN14 showing the effect of PTPN14 on Endoglin and SMAD4 level with the quantification graph ( E ). F : siRNA-treated cells Western blot of HUAECs cell lysates after 1h treatment with TGFβ (2ng/ml) or BMP9 (2ng/ml), with or without 5uM K02288 (an ALK-1 inhibitor) or 5uM SB431542 (a TGFβR1 inhibitor) with the observation of SMAD4, pSMAD1 and total Smad1 level trough the different conditions. G: Co-immunoprecipitation of endogenous PTPN14, SMAD4, Endoglin, ALK-1 SMAD7, or IgG control, shows interaction between endogenous PTPN14 and SMAD4,but not with Endoglin, ALK-1 and, SMAD7. H: SMAD4 pulldown with SMAD4, TAZ, pTAZ, pSAMD1/5, and SMAD7 is showing the interaction of SMAD4 with the different proteins.

    Journal: bioRxiv

    Article Title: The YAP/TAZ antagonist, PTPN14, stabilizes SMAD4 through direct interactions in endothelial cells: Implications for Hereditary Hemorrhagic Telangiectasia

    doi: 10.1101/2021.09.29.462397

    Figure Lengend Snippet: A: Sub-confluent HUAECs were transfected with specified siRNAs , protein lysates were harvested 48 hours later, following the indicated treatments for 0, 1 or 24 hours with BMP9 (2ng/ml), and assayed by Western blot (left) with B: Histograms (right) showing quantification of proteins relative to siNT -transfected HUAECs. C: Schematic of BMP9-ALK-1-SMAD4 signaling. D&E : Western blot from HUAEC treated with 2ng/ml of BMP9 for 24h using siNT compared to siPTPN14 showing the effect of PTPN14 on Endoglin and SMAD4 level with the quantification graph ( E ). F : siRNA-treated cells Western blot of HUAECs cell lysates after 1h treatment with TGFβ (2ng/ml) or BMP9 (2ng/ml), with or without 5uM K02288 (an ALK-1 inhibitor) or 5uM SB431542 (a TGFβR1 inhibitor) with the observation of SMAD4, pSMAD1 and total Smad1 level trough the different conditions. G: Co-immunoprecipitation of endogenous PTPN14, SMAD4, Endoglin, ALK-1 SMAD7, or IgG control, shows interaction between endogenous PTPN14 and SMAD4,but not with Endoglin, ALK-1 and, SMAD7. H: SMAD4 pulldown with SMAD4, TAZ, pTAZ, pSAMD1/5, and SMAD7 is showing the interaction of SMAD4 with the different proteins.

    Article Snippet: BMP9 signaling inhibition was performed using an ALK-1 kinase small molecule inhibitor K02288 5 μM (#S7359, Selleckchem®).

    Techniques: Transfection, Western Blot, Immunoprecipitation, Control